Anti Aging with EGF Serum What can the active ingredient EGF serum really do? Wed, 11 Oct 2017 11:49:26 +0000 en-GB hourly 1 136257380 Epidermal Growth Factor Mon, 18 Sep 2017 13:02:08 +0000 Read more]]> Informationen über den Hautwachstumsfaktor EGF

Der EGF fördert:

  • das Hautwachstum,
  • die Hautregeneration,
  • den Hautwiederaufbau und
  • die Wundheilung.

Quelle: By Chua K, Sim W, Racine V, Lee S, Goh B, Thiery J [CC BY 2.5 (], via Wikimedia Commons.

What to know about EGF: the science behind it

The epidermal growth factor (EGF), is a protein (polypeptide) and signaling molecule, a natural component of the skin which stimulates cell growth and regulates cell proliferation (proliferation is the growth of cell tissue). Growth factors are proteins which carry signals from one cell to another (signal proteins), thus transmitting information.

With increasing age, the body produces less and less EGF. By providing more EGF to the body, the cell turnover can be increased once again. It is then transmitted to the EGF receptors of the skin cells and communicates with the DNA to promote skin renewal. The cells relay this pulse to their neighbouring cells. This signal continues to the collagen producing cells in the deeper layers of the skin. The EGF thus acts as a cell-activating messenger, which ensures that regeneration and healing processes are set into motion quickly.

Through the accelerated cell renewal, the skin’s aging process is counteracted and the renewal process is enhanced and optimized. Thanks to the cell, elastin and collagen regeneration: skin stability is improved and the skin density can be increased by up to 30%. The skin the skin remains smooth and elastic and wrinkles are reduced. Due to the increase collagen production, the skin becomes firmer.

In 1986, the discovery of the EGF and its effects were awarded the Nobel Prize for Medicine.

The EGF proteins interact with four different receptors: HER1 (also EGF Receptor), HER2, HER3 and HER4. The epidermal growth factor receptors (HER1), serve as a binding protein on the cell’s surface. Through this interaction, information is passed on, which leads to different cell types being stimulated, enabling the skin to regenerate faster and more efficiently. In the membrane of a healthy cell, approximately 40,000 to 100,000 EGFR molecules are present. Activation of the EGF receptor is achieved by extracellular binding of ligands, such as: EGF, transforming growth factor-a (TGF-a), heparin-binding EGF and others whose signal is directed to the cell interior (signal transduction). This results in the stimulation of cell growth and the optimization of apoptosis, programmed cell death.

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Fibroblast Growth Factors Mon, 18 Sep 2017 13:01:16 +0000 Read more]]> Informationen über die Fibroblasten Wachstumsfaktoren

Fibroblast Growth Factor 9 (FGF9, Glia-activating factor) protein. Plays essential role in male development (sex determination).Sie fördern:

  • das Zellwachstum,
  • die Kollagensynthese,

zudem erhöhen sie:

  • die Spannkraft und
  • Festigkeit der Haut.

What to know about FGFs: the science behind it

The fibroblast growth factors (FGF) consist of a group of growth factors called the FGF family. The FGFs are very important proteins, more specifically signal proteins, which regulate cell growth and the differentiation between cells. They also control and stimulate proliferation, migration and distinction of cells – particularly muscle cells and fibroblasts.

The most important product that the fibroblasts produce, is collagen. The collagen is synthesized in the rough endoplasmic reticulum (ER). The rough ER lets its own membrane grow and directs membrane parts to other sections of the internal membrane system. Once the fibroblasts are synthesized, they are the most important fiber component of the skin, bone, tendons, cartilage, blood vessels and teeth. They are responsible for the strength and tension of the skin’s surface. The collagen synthesis is stimulated by the FGFs, so that the skin retained longer smooth and wrinkle-free.

Until today, 23 members of the FGF group are known: FGF 1 to 23. In the 1970’s the first FGFs were discovered. Initially it was thought that they act exclusively on fibroblasts (the cells which are a major component of the connective tissue), they were named fibroblast growth factors. However, it was discovered later that FGFs have other and more general functions which influence almost all cells.

FGFs play a key role in embryonic development. In adults, FGFs control tissue-relevant processes and play an active role in wound healing and angiogenesis (the formation of new vessels). It also regenerates the nerves and cartilage tissue. The distinction between cell and tissue is not possible without FGFs. The receptors of the FGFs are located superficially on the outer cell membranes. The FGFs then carry signals to the cell interior. They also initiate healing and repair mechanisms of the body. The FGFs are essential in the wound healing process (eg. diabetic ulceration), since they, in particular FGF-1, act in a healing – promoting and accelerating manner.

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